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Probing the evolutionary robustness of two repurposed drugs targeting iron uptake in Pseudomonas aeruginosa
[article]
2017
bioRxiv
pre-print
Treatments that inhibit the expression or functioning of bacterial virulence factors hold great promise to be both effective and exert weaker selection for resistance than conventional antibiotics. However, the evolutionary robustness argument, based on the idea that anti-virulence treatments disarm rather than kill pathogens, is controversial. Here we probe the evolutionary robustness of two repurposed drugs, gallium and flucytosine, targeting the iron-scavenging pyoverdine of the
doi:10.1101/195974
fatcat:v7ta5cegkffdnktibmlwxagh6e