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Despite thousands of influenza cases annually recorded by surveillance systems around the globe, estimating the transmission patterns of seasonal influenza is challenging. Methods We develop an age-structured mathematical model to influenza transmission to analyze ten consecutive seasons (from 2010-2011 to 2019-2020) of influenza epidemiological and virological data reported to the Italian surveillance system. Results We estimate that 18.4%-29.3% of influenza infections are detected by thedoi:10.1101/2020.11.29.20240457 fatcat:zar34n5br5ay7hcl66txvo7ipi