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Elastic transformation of histological slices allows precise co-registration with microCT data sets for a refined virtual histology approach
Although x-ray based 3D virtual histology is an emerging tool for the analysis of biological tissue, it falls short in terms of specificity when compared to conventional histology. Thus, the aim was to establish a novel approach that combines 3D information provided by microCT with high specificity that only (immuno-)histochemistry can offer. For this purpose, we developed a software frontend, which utilises an elastic transformation technique to accurately co-register various histological anddoi:10.21203/rs.3.rs-208394/v1 fatcat:tcg6imje4vdqhagaajdg5f4wq4