Hepatitis C virus genotypes in Córdoba, Argentina. Unexpected high prevalence of genotype 2

Viviana Ré, Elisabeth Lampe, Clara Fumiko Yoshida, Jaqueline Mendes de Oliveira, Lia Lewis-Ximénez, Lorena Spinsanti, Osvaldo Elbarcha, Marta Contigiani
2003 Medicina (Buenos Aires)  
To determine hepatitis C virus (HCV) genotypes circulating in the central region of Argentina, 96 consecutive anti-HCV positive subjects were studied. The presence of HCV RNA was detected in 60 samples by RT-nested PCR of the 5' noncoding region (5' NCR). Genotyping was performed by restriction fragment length polymorphism analysis of 5' NCR region combined with PCR using type-specific primers of the core region. The groups of individuals in this study included hemophilia and hemodialysis
more » ... hemodialysis patients, injecting drug users, screened blood donors, and patients with acute or chronic liver disease, all from Córdoba, Argentina. Overall, genotype 2 was the most prevalent (55.0%), followed by genotypes 1 (38.3%), and 3 (5.0%). Within genotype 1, subtype 1b was the most prevalent. An unexpected high prevalence of genotype 2 (61.9%) was found among patients with acute or chronic HCV infection (without known risk factors). These figures differ from other cohorts from East-Argentina where genotype 1 has been found as the most prevalent. This indicates that regional differences of genotype distribution might exist between Central and East Argentina.
pmid:12876903 fatcat:c4djfeap3rev3nqglupd6wjcwm