Blood lymphocyte cultures from two groups of workers occupationally exposed to uranium were examined for asymmetrical chromosome aberrations and sister chromatid exchanges (SCEs). Significant increases in both cytogenetic endpoints were seen. For dicentrics this appeared to be particularly associated with exposure to soluble uranium. The external radiation exposure experienced by these men was insufficient to explain the increase in dicentrics, and irradiation of lymphocytes by internally

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... ted uranium would have been minimal. As the SCEs were