Computation Details; -S1--Optimized structures and selected geometric parameters of the stationary points along the hydrolysis reaction paths; a) Trans-EE and b) Trans-EE/Met; -S2--Natural Bond charges of the stationary points located along the hydrolysis paths for a) Trans-EE and b) Trans-EE/Met complexes; -S3--Selected calculated Wiberg bond index for Pt-Cl leaving group and Pt-O water during the hydrolysis reactions for a) Trans-EE and b) Trans-EE/Met complexes; -S4--Homo-Lumo molecular

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... al plots for the stationary points along the hydrolysis reaction path for Trans-EE compound; -S5--Homo-Lumo molecular orbital plots for the stationary points along the hydrolysis reaction path for Trans-EE/Met compound; -S6--Optimized structures and selected geometric parameters of the stationary points for the binding of Guanine base to a)Trans-EE and b)Trans-EE/Met; -S7--Homo-Lumo molecular orbital plots and G-N7 lone-pairs energies for Trans-EE and Trans-EE/Met transition state structures; -S8--Optimized structures and selected geometric parameters of the stationary points for the binding of Adenine base to a)Trans-EE and b) Trans-EE/Met; -S9--Natural Bond charges of the stationary points of the reaction with Guanine base a) Trans-EE and b) Trans-EE/Met complexes; -S10--References; -S11-Supplementary Material (ESI)