Formate: an essential metabolite, a biomarker, or more?

Simon G. Lamarre, Gregory Morrow, Luke Macmillan, Margaret E. Brosnan, John T. Brosnan
2013 Clinical Chemistry and Laboratory Medicine  
Plasma and urinary formate concentrations were recently found to be elevated during vitamin B12 and folate deficiencies. It was proposed that formate may be a valuable biomarker of impaired one-carbon metabolism. Formate is an essential intermediary metabolite in folate-mediated one-carbon metabolism and, despite its importance, our knowledge of its metabolism is limited. Formate can be produced from several substrates (e.g., methanol, branched chain fatty acids, amino acids), some reactions
more » ... ng folate-dependent while others are not. Formate removal proceeds via two pathways; the major one being folate-dependent. Formate is a potentially toxic molecule and we suggest that formate may play a role in some of the pathologies associated with defective one-carbon metabolism.
doi:10.1515/cclm-2012-0552 pmid:23241677 fatcat:bqabt4tuyjb4zol5khvo3skpxm