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Improved recognition of native‐like protein structures using a combination of sequence‐dependent and sequence‐independent features of proteins
1999
Proteins: Structure, Function, and Bioinformatics
We describe the development of a scoring function based on the decomposition P(structure 0 sequence) ϰ P(sequence 0 structure) *P(structure), which outperforms previous scoring functions in correctly identifying native-like protein structures in large ensembles of compact decoys. The first term captures sequence-dependent features of protein structures, such as the burial of hydrophobic residues in the core, the second term, universal sequence-independent features, such as the assembly of
doi:10.1002/(sici)1097-0134(19990101)34:1<82::aid-prot7>3.3.co;2-1
pmid:10336385
fatcat:ogofbwdzanbdzfeficekvgunti