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Dynamic sensitivity and nonlinear interactions influence the system-level evolutionary patterns of phototransduction proteins
2015
Proceedings of the Royal Society of London. Biological Sciences
Determining the influence of complex, molecular-system dynamics on the evolution of proteins is hindered by the significant challenge of quantifying the control exerted by the proteins on system output. We have employed a combination of systems biology and molecular evolution analyses in a first attempt to unravel this relationship. We employed a comprehensive mathematical model of mammalian phototransduction to predict the degree of influence that each protein in the system exerts on the
doi:10.1098/rspb.2015.2215
pmid:26631565
pmcid:PMC4685781
fatcat:fhzm2bmwzzfhzlxlo426dxywru