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EMD638683, a Novel SGK Inhibitor with Antihypertensive Potency
Cellular Physiology and Biochemistry
The serum-and glucocorticoid-inducible kinase 1 (SGK1) is transcriptionally upregulated by mineralocorticoids and activated by insulin. The kinase enhances renal tubular Na + -reabsorption and accounts for blood pressure increase following high salt diet in mice made hyperinsulinemic by dietary fructose or fat. The present study describes the in vitro and in vivo efficacy of a novel SGK1 inhibitor (EMD638683). EMD638683 was tested in vitro by determination of SGK1-dependent phosphorylation ofdoi:10.1159/000331722 pmid:21865856 fatcat:jk3qz7a2hjhtzcyg2humkk2lzm