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A Machine Learning Framework Predicts the Clinical Severity of Hemophilia B Caused by Point-Mutations
2022
Frontiers in Bioinformatics
Blood coagulation is a vital physiological mechanism to stop blood loss following an injury to a blood vessel. This process starts immediately upon damage to the endothelium lining a blood vessel, and results in the formation of a platelet plug that closes the site of injury. In this repair operation, an essential component is the coagulation factor IX (FIX), a serine protease encoded by the F9 gene and whose deficiency causes hemophilia B. If not treated by prophylaxis or gene therapy,
doi:10.3389/fbinf.2022.912112
fatcat:odgatognyvfh3i4bq2b7w6gcsa