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Evidence for a direct cross-talk between malic enzyme and the pentose phosphate pathway via structural interactions
2017
Journal of Biological Chemistry
Edited by John M. Denu Recent studies have revealed that the oxidative pentose phosphate pathway (PPP), malic enzyme (ME), and folate metabolism are the three major routes for generating cellular NADPH, a key cofactor involved in redox control and reductive biosynthesis. Many tumor cells exhibit altered NADPH metabolism to fuel their rapid proliferation. However, little is known about how NADPH metabolism is coordinated in tumor cells. Here we report that ME1 increases the PPP flux by forming
doi:10.1074/jbc.m117.810309
pmid:28848047
fatcat:fps5f54boretdnevmsvjlbbd7y