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Dysregulated wild-type cell division at the interface between host and oncogenic epithelium
[article]
2019
bioRxiv
pre-print
Carcinomas dysregulate their microenvironment and this helps aid disease progression, in part by altering the behaviour of host cells from different lineages, such as immune and endothelial cells. However, it remains largely unknown whether small groups of cells with initial oncogenic changes alter their environment or affect fundamental processes, such as cell division, in host epithelia. In this study, clusters of oncogene-expressing cells were created within otherwise normal, in vivo tissue,
doi:10.1101/578146
fatcat:tl2asjgqo5cbxj6bg2ia2hhaji