Pleomorphic adenoma of salivary gland and synchronous/metachronous invasive ductal breast cancer: a casual coincidence or a clinical presentation resulting from common genetic events?

Francesco Longo, Rocco Sabatino, Gabriella Aquino, Nunzia Losito, Monica Cantile, Franco Ionna, Gerardo Botti
2018 Int J Clin Exp Pathol   unpublished
Breast and salivary glands have similar morphological and pathological features; however genetic relation between these lesions were not described. In this report we described a small series of biomarkers that developed synchronously or metachronous pleomorphic adenoma of the salivary glands and invasive breast cancer, on which we have tested, by immunohistochemistry, several of bio-markers that may be associated with the pathogenesis of both malignancies. In conclusion, we suggest to better
more » ... uggest to better investigate early genetic alterations that could underlie of the synchronous occurrence of these lesions.