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Deletion of protein tyrosine phosphatase 1b in proopiomelanocortin neurons reduces neurogenic control of blood pressure and protects mice from leptin- and sympatho-mediated hypertension
2015
Pharmacological Research
Keywords: Proopiomelanocortin neurons Protein tyrosine phosphatase 1b Leptin Neurogenic control of blood pressure Vascular adrenergic reactivity a b s t r a c t Protein tyrosine phosphatase 1b (Ptp1b), which represses leptin signaling, is a promising therapeutic target for obesity. Genome wide deletion of Ptp1b, increases leptin sensitivity, protects mice from obesity and diabetes, but alters cardiovascular function by increasing blood pressure (BP). Leptin-control of metabolism is centrally
doi:10.1016/j.phrs.2015.10.012
pmid:26523876
fatcat:f3a76cwt4zg7zm4cdxbbvpw4lu