Organocatalytic Asymmetric Michael Addition of 1,3-Cyclohexanedione to Benzylidenemalonitriles

Chang Won Suh, Dae Young Kim
2014 Bulletin of the Korean Chemical Society (Print)  
The organocatalytic enantioselective Michael addition reaction promoted by chiral binaphthyl-modified squaramide catalyst have been developed, allowing facile synthesis of the corresponding chiral 2-amino-4Hchromenes derivatives with excellent enantioselectivity (up to 99% ee). The method reported represents a practical entry for the preparation of chiral 2-amino-4H-chromenes derivatives.
doi:10.5012/bkcs.2014.35.1.98 fatcat:2ec3sv2bcfgo7ay475lwhroh3i