Fasting Insulin and Obesity-Related Phenotypes Are Linked to Chromosome 2p: The Strong Heart Family Study

V. P. Diego, H. H.H. Goring, S. A. Cole, L. Almasy, T. D. Dyer, J. Blangero, R. Duggirala, S. Laston, C. Wenger, T. Cantu, B. Dyke, K. North (+6 others)
2006 Diabetes  
To localize quantitative trait loci for insulin metabolism and obesity, genome scans/linkage analyses were performed on >900 members of 32 extended families participating in phase 3 of the Strong Heart Study, an investigation of the genetic and environmental determinants of cardiovascular disease in American-Indian populations from Arizona, Oklahoma, and North and South Dakota. Linkage analyses of fasting insulin and two obesity-related phenotypes, BMI and percent fat mass, were performed
more » ... ndently in each of the three populations. For log fasting insulin, we found a genome-wide maximum, robust logarithm of odds (LOD) score of 3.42 at 51 cM on chromosome 2p in the Dakotas. Bivariate linkage analyses of log fasting insulin with both BMI and fat mass indicate a situation of incomplete pleiotropy, as well as several significant bivariate LOD scores in the Dakotas. FIG. 2. Bivariate linkage signals for log fasting insulin in relation to obesity-related phenotypes from the Dakotas center. Dashed line, log fasting insulin plus BMI; solid line, log fasting insulin plus fat mass.
doi:10.2337/db05-0668 pmid:16731856 fatcat:r53coylowbb4ldn4d7pz3o5kpy