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The Emperor's new clothes: Myths and truths of in-cell NMR
Archives of Biochemistry and Biophysics
In-cell NMR is a technique developed to study the structure and dynamical behavior of biological macromolecules in their natural environment, circumventing all isolation and purification steps. In principle, the potentialities of the technique are enormous, not only for the possibility of bypassing all purification steps but, even more importantly, for the wealth of information that can be gained from directly monitoring interactions among biological macromolecules in a natural cell. Here, wedoi:10.1016/j.abb.2017.02.008 pmid:28259514 fatcat:exkguapdyvd35cnqrd3hnukngi