This study investigates the use of [Tc99m] liposome agents for the assessment of nuclear medicine purposes. A variety of [99mTc] liposome formulations were compared with common lymphoscintigraphic agents including [Tc99m] regular-sulfur colloid (SC), and [Tc99m] human serum albumin (HSA) besides assisting the use of positive charged liposomes in rabbits. 10 male rabbits (2-2.5 kg) were anesthetized with ketamine:xylazine intramuscularly. Then they were injected with different [Tc99m] liposome

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... ents subcutaneously in the dorsum of each hind foot over the region of the metatarsals at the midline as well as intravenously. Dynamic (1 minute) scintigraphic images were acquired in a 256x1024 image matrix using a symbia gamma camera as early images and for the first 60 minutes post injection. This was followed by testing the tissue biodistribution by calculating the percentage of the injected dose (% ID) per organ for each (Tc99m) agent and studying the heart/liver, heart/bone marrow, and heart/kidneys ratio. All agents demonstrated good migration from the injection site to blood pool but not to lymphatic drainage. Agents were starting to clear out rapidly after 60 minutes. [Tc99m] liposome imaging can be used to develop novel liposome compositions with improved cardiac diagnostic and drug delivery characteristics.