Immobilisation of Cells in Biocompatible Films to Cell Therapy

Eva. M. Martin Del Valle, Edgar P. Herrero, Dina A.O. Martins, Miguel. A. Galan
2009 The Open Tissue Engineering and Regenerative Medicine Journal  
In this work a new system for immobilisation of cells was developed based on biocompatible alginate bariumfilms. Films are prepared to allow better control over film thickness and produce better film uniformity, avoiding roughness over film surface that can produce fibrosis and rejection after transplantation. In this study monocyte, mononuclear and fibroblast cell lines were immobilised in micrometric ( 300 microns of thickness) barium alginate films. The system was able to maintain the cell
more » ... ability of all the three types of cells for at least two weeks after immobilisation, but cell proliferation was only verified for the monocyte and fibroblast cell lines. © Del Valle et al.; Licensee Bentham Open. This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
doi:10.2174/1875043500902010014 fatcat:7q6ywfon4bh5plgctt4vl66xja