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The objective of this study was to investigate the seasonal variance of the content and chemical composition of the essential oil from Lantana camaraaccessions at two harvest times, and to analyze the trypanocidal activity on Phytomonas serpens. Essential oil content ranged from 0.13 to 0.29% in the rainy season and from 0.13 to 0.33% in the dryseason. The compounds E-caryophyllene, α-humulene, α-curcumene and germacrene D defined the formation of four chemical clusters in the rainy and drydoi:10.37360/blacpma.22.214.171.124 fatcat:uhm5pxcjqrarhov3cj5fugypgq