Assessment of dynamic susceptibility contrast cerebral blood flow response to amphetamine challenge: A human pharmacological magnetic resonance imaging study at 1.5 and 4 T

Stephen E. Rose, Andrew L. Janke, Mark W. Strudwick, Katie L. McMahon, Jonathan B. Chalk, Peter Snyder, Greig I. De zubicaray
2005 Magnetic Resonance in Medicine  
Pharmacological MRI (phMRI) techniques can be used to monitor the neurophysiological effects of central nervous system (CNS) active drugs. In this study, we investigated whether dynamic susceptibility contrast (DSC) perfusion imaging employing the use of superparamagnetic iron oxide nanoparticles (Resovist) could be used to measure hemodynamic response to d-amphetamine challenge in human subjects at both 1.5 and 4 T. Significant changes in cerebral blood flow (CBF) were found in focal regions
more » ... sociated with the nigrostriatal circuit and mesolimbic and mesocortical dopaminergic pathways. More significant CBF responses were found at higher field strength, mainly within striatal structures. The results from this study indicate that DSC perfusion imaging using Resovist can be used to assess the efficacy of CNS-active drugs and may play a role in the development of novel psychiatric therapies at the preclinical level. Magn Reson Med 55:9 -15, 2006.
doi:10.1002/mrm.20749 pmid:16342159 fatcat:3qy7tbmuzzga7kmd4nvie2e4ri