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Neuroendocrine prostate cancer is a rare entity. It can be presented in a pure form (small or large cell neuroendocrine carcinoma) or in a mixed form, i.e. associated with an adenocarcinomatous contingent. Neuroendocrine carcinoma of the prostate poses both diagnostic and therapeutic problems. Nevertheless, it is a heterogeneous entity encompassing a multitude of histopathological forms with distinct clinical features. Prostate neuroendocrine tumors are often associated with an adenocarcinoma,doi:10.36347/sasjs.2022.v08i05.007 fatcat:buhtmvp2vndwlgsmeza4utdsre