Analytical Method Development and Validation of Entacapone Drug by Modern LC-MS/MS Method to Quantify the Genotoxic Impurity

Krishna Murali, Vallabhaneni, Anjaneyulu Yerramilli, Rajendiran Chinnapillai, Yesu Nalamolu
Journal of Chemical and Pharmaceutical Research   unpublished
A new high sensitive and specific LC-MS/MS (Liquid chromatography coupled with tandem mass spectrometric detection) method was developed and validated for the determination Toronto/Canada" Mass Detectors. As part of the method validation, system suitability, specificity, limit of detection (LOD), limit of quantification (LOQ), linearity, accuracy, precision, and stability of stock solutions were determined.
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