There are credible data that the indirect relationship of sense of coherence with well-being can involve potential mediation and moderation mechanisms related to emotional and meaning-oriented factors. The self-concordance model provides a theoretical framework through which these associations can be examined. The current research explored whether the relationship between sense of coherence and well-being in people with coronary heart disease can be mediated by affect and simultaneously

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... d by meaning in life. A total of 176 patients with coronary heart disease completed four questionnaires. Positive and negative affect turned out to mediate, though differently, the relationship between feelings of coherence and well-being. Furthermore, meaning in life moderated the indirect effect of sense of coherence to well-being only through positive affect. This confirmed the validity of a moderated mediation model of affect and meaning in life in associations between sense of coherence and well-being in people with coronary heart disease problems.