A REVIEW ON ORAL LIPOSPHERE OF CANDESARTAN CILEXETIL

Madhukanwar Rathore, Manish Kumar Gupta, Vijay Sharma
International Journal of Pharmaceutical and Biological Science Archive Index Copernicus Value: 43   unpublished
Lipospheres are amongst the promising particulate drug delivery systems for improving dissolution rate of water insoluble drugs that were initially reported as a particulate dispersion of solid spherical particles between 0.2-100μm in diameter consisting of solid hydrophobic fat core such as triglycerides or fatty acids derivatives, stabilized by monolayer of phospholipids. The lipospheres are distinct from microspheres of uniformly dispersed material in homogenous polymer since they consist of
more » ... nce they consist of two layers, the inner solid particle that contains the entrapped drug with phospholipids outer layer. Many of the drug substances are characterized by poor aqueous solubility, which cause many formulation problems. Beside the use of so-solvents, drug complexation and solubilization in surfactant micelles, incorporation in colloidal carrier system represents an alternative way to render poorly water soluble drug applicable for effective therapy.
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