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Approaches to Enhance Natural Killer Cell-Based Immunotherapy for Pediatric Solid Tumors
Treatment of metastatic pediatric solid tumors remain a significant challenge, particularly in relapsed and refractory settings. Standard treatment has included surgical resection, radiation, chemotherapy, and, in the case of neuroblastoma, immunotherapy. Despite such intensive therapy, cancer recurrence is common, and most tumors become refractory to prior therapy, leaving patients with few conventional treatment options. Natural killer (NK) cells are non-major histocompatibility complexdoi:10.3390/cancers13112796 fatcat:zlz57rgob5elnacma6uvkciafe