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The traditional design of effective vaccines for rapidly-evolving pathogens, such as influenza A virus, has failed to provide broad spectrum and long-lasting protection. With low cost whole genome sequencing technology and powerful computing capabilities, novel computational approaches have demonstrated the potential to facilitate the design of a universal influenza vaccine. However, few studies have integrated computational optimization in the design and discovery of new vaccines.doi:10.3390/vaccines7020045 pmid:31141933 pmcid:PMC6631137 fatcat:difxw2yy4vdxrg257jytohqfeq