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Anal skin-like epithelium mediates colonic wound healing
[article]
2021
bioRxiv
pre-print
Intestinal epithelial wound healing, which is essential for health, is compromised and represents a therapeutic target in inflammatory bowel disease (IBD). While studies have elucidated important subpopulations of intestinal epithelial cells in repair, these have yet to translate to therapies. Here, in mouse models of acute colitis, we demonstrate a distinct and essential source of wound-healing cells that re-epithelialize the distal colon. Using 3-d imaging, lineage tracing, and single-cell
doi:10.1101/2021.06.02.446836
fatcat:3bz4yymv2ze2hiurjrpria77ne