Micro- and nano-structure based oligonucleotide sensors

David C. Ferrier, Michael P. Shaver, Philip J.W. Hands
<span title="">2015</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ttvkaebpgrb6fiziwhp5jpanv4" style="color: black;">Biosensors &amp; bioelectronics</a> </i> &nbsp;
This paper presents a review of micro-and nano-structure based oligonucleotide detection and quantification techniques. The characteristics of such devices make them very attractive for Point-of-Care or On-Site-Testing biosensing applications. Their small scale means that they can be robust and portable, their compatibility with modern CMOS electronics means that they can easily be incorporated into hand-held devices and their suitability for mass production means that, out of the different
more &raquo; ... oaches to oligonucleotide detection, they are the most suitable for commercialisation. This review discusses the advantages of micro-and nano-structure based sensors and covers the various oligonucleotide detection techniques that have been developed to date. These include: Bulk Acoustic Wave and Surface Acoustic Wave devices, micro-and nano-cantilever sensors, gene Field Effect Transistors, and nanowire and nanopore based sensors. Oligonucleotide immobilisation techniques are also discussed.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.bios.2015.01.031">doi:10.1016/j.bios.2015.01.031</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25655465">pmid:25655465</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/fln3szuatja5veflut7iztz6ly">fatcat:fln3szuatja5veflut7iztz6ly</a> </span>
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