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The high-throughput perturbation of long non-coding RNA reveals functional features in stem cells and across cell-types
[article]
2022
bioRxiv
pre-print
Long non-coding RNAs (lncRNAs) were shown to regulate pluripotency and differentiation, however, a comprehensive assessment of their regulatory roles in stem cells is currently lacking. By performing a large-scale knockdown of lncRNAs (n = 390) in human induced pluripotent stem (iPS) cells, we systematically characterized their roles in self-renewal and pluripotency. Cell growth and transcriptomic assays revealed respectively, 18.3% and 29.3% of these lncRNAs in altering cellular and molecular
doi:10.1101/2022.02.16.480297
fatcat:adnyvqfvgnbtnlkg2xmiiovxz4