Rich-club neurocircuitry: function, evolution, and vulnerability

Alessandra Griffa, Martijn P Van den Heuvel
2018 Dialogues in Clinical Neuroscience  
Over the past decades, network neuroscience has played a fundamental role in the understanding of large-scale brain connectivity architecture. Brains, and more generally nervous systems, can be modeled as sets of elements (neurons, assemblies, or cortical chunks) that dynamically interact through a highly structured and adaptive neurocircuitry. An interesting property of neural networks is that elements rich in connections are central to the network organization and tend to interconnect
more » ... with each other, forming so-called rich clubs. The ubiquity of rich-club organization across different species and scales of investigation suggests that this topology could be a distinctive feature of biological systems with information processing capabilities. This review surveys recent neuroimaging, computational, and cross-species comparative literature to offer an insight into the function and origin of rich-club architecture in nervous systems, discussing its relevance to human cognition and behavior, and vulnerability to brain disorders.
pmid:30250389 pmcid:PMC6136122 fatcat:mvlpxiyhsjgd5a7p6xz6kyg6fa