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Dynamics of constitutive heterochromatin: two contrasted kinetics of genome restructuring in early cloned bovine embryos
2010
Reproduction
Efficient reprograming of the donor cell genome in nuclear transfer (NT) embryos is linked to the ability of the embryos to sustain full-term development. As the nuclear architecture has recently emerged as a key factor in the regulation of gene expression, we questioned whether early bovine embryos obtained from transfer of cultured fibroblasts into enucleated oocytes would adopt an embryo-like nuclear organization. We studied the dynamics of constitutive heterochromatin in the stages prior to
doi:10.1530/rep-08-0435
pmid:19778997
fatcat:pdrlsyekk5fdzmqprqe7vbv2ca