Purpose: Non-rigid image registration (NIR) is useful for adaptive radiotherapy. However, no method has been established for evaluating the quality of the algorithms used in NIR. To remedy this situation, we demonstrate herein a novel method to evaluate NIR algorithms. Methods: We define the NIR error as the discrepancy distance between (i) the organ contours obtained from computed tomography (CT) images acquired during the treatment period (reference contours) and (ii) the contours obtained

more »

... m the treatment-planning CT images that are constructed by automated propagation during the treatment period (evaluation contours). However, the continuous positional relationship between the points where the reference contour intersects the evaluation contour is assumed to be maintained. In addition, we adapt the proposed method so that it can be applied to the contours of complex organs such as spherical and tubular organs. To demonstrate this method, we measure the contours of the prostate, right seminal vesicle, left seminal vesicle, urinary bladder, and rectum. The obtained NIR error presented in two-dimensional (2D) discrepancy maps. Results: The 2D discrepancy maps show the difference between the reference and evaluation contours from CT images. The proposed method measures the difference between the contours of spherical and tubular organs and evaluates the NIR error based on the positional relationship between the points constituting the contours. Conclusions: This study accounts for and measures the continuous positional relationship between corresponding points in the contours of complex-shaped spherical and tubular organs with irregularities and evaluates NIR algorithms based on these organ contours.