Inherited forms of bladder cancer: a review of Lynch syndrome and other inherited conditions

Aaron Phelan, Antonio Lopez-Beltran, Rodolfo Montironi, Shaobo Zhang, Maria R Raspollini, Monica Cheng, Hristos Z Kaimakliotis, Michael O Koch, Liang Cheng
2018 Future Oncology  
Environmental factors that play a role in the pathogenesis of bladder cancer have been characterized for many years. Current research into the pathophysiology of bladder cancers has begun to focus more on genetic alterations that are important in tumorigenesis. Low penetrance polymorphisms, such as N-acetyl transferase 2, glutathione S-transferase, and others have also shown to increase the risk of bladder cancer by altering the processing of environmental toxins. Additionally, Lynch syndrome
more » ... a well-known inheritable disease that increases the risk for a variety of cancers, including urothelial carcinomas. The development of bladder cancer is still not as well understood in Lynch syndrome as other classical Lynch syndrome associated cancers, such as colorectal and endometrial cancer. Research is continuously exploring potential heritable forms of bladder cancer. Screening of patients with known Lynch syndrome is also important to evaluate for development of new primary tumors. The focus of this article is to review the current available literature on familial bladder cancer variants, as well as to provide a review of Lynch syndrome and its association with urothelial tumors.
doi:10.2217/fon-2017-0346 pmid:29345160 fatcat:bfkmcsnpbneoho5oqoavioriwq