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Hemodynamic molecular imaging of tumor-associated enzyme activity in the living brain
Molecular imaging could have great utility for detecting, classifying, and guiding treatment of brain disorders, but existing probes offer limited capability for assessing relevant physiological parameters. Here we describe a potent approach for noninvasive mapping of cancer-associated enzyme activity using a molecular sensor that acts on the vasculature, providing a diagnostic readout via local changes in hemodynamic image contrast. The sensor is targeted at the fibroblast activation proteindoi:10.1101/2021.05.11.443603 fatcat:jmcqsdmxqvaohkf2b6pd6v5d5q