Functional disability and other health-related quality-of-life domains: points to consider for clinical trials in systemic sclerosis. Permalink https://escholarship.org/uc/item/53m0g1ct Journal Rheumatology (Oxford, England), 56(suppl_5) Abstract Patients with SSc have the highest mortality among the rheumatic diseases. In addition, SSc is associated with disfigurement, hand contractures, fatigue, poor sleep, severe RP with numbness and tingling of the fingers can lead to decrements in quality

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... f life. This Points to Consider article provides practical considerations for design of trials for functional disability and other health-related quality-of-life issues. Rheumatology key messages . Patients with SSc have decrements in health-related quality of life. . HAQ-Disability Index, UK Functional Score, SF-36 Physical Summary and PROMIS Physical Function meet OMERACT validation criteria in SSc. . Health-related quality-of-life measures can be secondary or exploratory outcomes in SSc trials with objective outcome measures.