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Functional disability and other health-related quality-of-life domains: points to consider for clinical trials in systemic sclerosis. Permalink https://escholarship.org/uc/item/53m0g1ct Journal Rheumatology (Oxford, England), 56(suppl_5) Abstract Patients with SSc have the highest mortality among the rheumatic diseases. In addition, SSc is associated with disfigurement, hand contractures, fatigue, poor sleep, severe RP with numbness and tingling of the fingers can lead to decrements in qualitydoi:10.1093/rheumatology/kex193 pmid:28992164 fatcat:abfbogmqy5gvtck36sxhr55umu