Severe hepatitis induced by cyproterone acetate: role of corticosteroids. A case report

Ludovico Abenavoli, Natasa Milic, Michel Beaugrand
Annals of Hepatology  
Cyproterone acetate (CPA) is an oral anti-androgen commonly used to treat advanced prostate cancer. A variety of hepatotoxic reactions has been reported with CPA. Here we describe a case of a male patient who developed severe drug-induced hepatotoxicity during the treatment with CPA. The case, presenting sub-acute hepatitis, was characterized by a rapid evolution of cirrhosis and a protracted activity during the period of a few months despite the treatment withdrawal and an apparent benefits of
more » ... corticosteroids, suggesting their indication in life threatening cases.
pmid:23293208 fatcat:bpft3imecvd6xctq6akfi5tawa