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The pathogenesis of colorectal cancer is a multifactorial process. Dysbiosis and the overexpression of COX‑2 and LDHA are important effectors in the initiation and development of the disease through chromosomal instability, PGE2 biosynthesis, and induction of the Warburg effect, respectively. Herein, we report the in vitro testing of some new quinoxalinone and quinazolinone Schiff's bases as: antibacterial, COX‑2 and LDHA inhibitors, and anticolorectal agents on HCT-116 and LoVo cells.doi:10.3390/molecules26113121 pmid:34071141 fatcat:emdiliubvbgmjlfsw6ptdu5hr4