Renal mixed epithelial and stromal tumor: case report

Karla Lais Pêgas, Eduardo Cambruzzi, Roque D. Furian, Antônio A. Hartmann, Suzana Elisabeth Lamonatto, Júlia M. Zanatta, Kárita Guimarães, Elizete Keitel, Giovani Thomaz Pioner
2015 Jornal Brasileiro de Patologia e Medicina Laboratorial  
Mixed epithelial and stromal tumor (MEST) represents a recently described biphasic kidney neoplasm, which predominantly affects perimenopausal females. The authors report the case of a young male patient with a MEST exhibiting positivity for estrogen and progesterone receptors. Computed tomography/magnetic resonance imaging (CT/MRI) showed an expansive lesion affecting the right kidney. Grossly, a solid-cystic tumor was identified, which measured 5.7 × 3.5 × 2.4 cm. On microscopic examination,
more » ... biphasic tumor constituted by stromal and epithelial elements, without significant atypias, was identified. The stromal element was composed of spindle cells revealing positive immunoexpression for actin, desmin, vimentin, and estrogen receptors. The epithelial component exhibited a predominantly tubular pattern showing positive immunoreaction for cytokeratins. The diagnosis of MEST was then established.
doi:10.5935/1676-2444.20150008 fatcat:63lnrs3le5g6dlli4kqshcts7y