Dietary intake of fish and the -3 fatty acids have been associated with lower risk of Alzheimer disease and stroke. Objective: To examine whether intakes of fish and the -3 fatty acids protect against age-related cognitive decline. Design: Prospective cohort study. Setting: Geographically defined Chicago, Ill, community. Participants: Residents, 65 years and older, who participated in the Chicago Health and Aging Project. Main Outcome Measure: Change in a global cognitive score estimated from

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... xed models. The global score was computed by summing scores of 4 standardized tests. In-home cognitive assessments were performed 3 times over 6 years of follow-up. Results: Cognitive scores declined on average at a rate of 0.04 standardized units per year (SU/y). Fish intake