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Tandem mass spectrometry - especially in combination with liquid chromatography (LC-MS/MS) - is applied in a multitude of important diagnostic niches of laboratory medicine. It is unquestioned in its routine use and is often unreplaceable by alternative technologies. This overview illustrates the development in the past decade (2009-2019) and intends to provide insight into the current standing and future directions of the field. The instrumentation matured significantly, the applications aredoi:10.1016/j.clinbiochem.2020.03.004 pmid:32188572 fatcat:shxgfmrk5fgkjinkzsbqc5fmte