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Bonilla-Felix, Melvin. Development of water transport in the collecting duct. .-The ability of the immature kidney to concentrate urine is lower than in adults. This can lead to severe water and electrolyte disorders, especially in premature babies. Resistance to AVP and lower tonicity of the medullary interstitium seem to be the major factors limiting urine concentration in newborns. AVP-stimulated cAMP generation is impaired. This is the result of inhibition of the production by PGE 2 actingdoi:10.1152/ajprenal.00119.2004 pmid:15522987 fatcat:5mf5r7nkcnadblirxkwhlqjypm