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Quantitation of herpes simplex virus type 1 DNA and latency-associated transcripts in rabbit trigeminal ganglia demonstrates a stable reservoir of viral nucleic acids during latency
1996
Journal of Virology
In this investigation we determined the dynamics of herpes simplex virus type 1 (HSV-1) DNA and latencyassociated transcripts (LAT) in the latently infected rabbit trigeminal ganglion. Rabbit eyes were infected with either the McKrae strain or the 17Syn ؉ strain of HSV-1. Rabbits were sacrificed between 5 and 360 days after infection and their trigeminal ganglia were analyzed for the number of HSV DNA genomes and the number of neuronal cells expressing LAT. There was no statistically
doi:10.1128/jvi.70.5.3137-3141.1996
fatcat:kk3e7jnbtjb65lt2t7yix27p6e