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Quantitation of herpes simplex virus type 1 DNA and latency-associated transcripts in rabbit trigeminal ganglia demonstrates a stable reservoir of viral nucleic acids during latency
Journal of Virology
In this investigation we determined the dynamics of herpes simplex virus type 1 (HSV-1) DNA and latencyassociated transcripts (LAT) in the latently infected rabbit trigeminal ganglion. Rabbit eyes were infected with either the McKrae strain or the 17Syn ؉ strain of HSV-1. Rabbits were sacrificed between 5 and 360 days after infection and their trigeminal ganglia were analyzed for the number of HSV DNA genomes and the number of neuronal cells expressing LAT. There was no statisticallydoi:10.1128/jvi.70.5.3137-3141.1996 fatcat:kk3e7jnbtjb65lt2t7yix27p6e