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The genomic instability associated with integrated simian virus 40 DNA is dependent on the origin of replication and early control region
1994
Journal of Virology
DNA rearrangements in the form of deletions and duplications are found within and near integrated simian virus 40 (SV40) DNA in nonpermissive cell lines. We have found that rearrangements also occur frequently with integrated pSV2neo plasmid DNA. pSV2neo contains the entire SV40 control region, including the origin of replication, both promoters, and the enhancer sequences. Linearized plasmid DNA was electroporated into Xl, an SV40-transformed mouse cell line that expresses SV40 large T antigen
doi:10.1128/jvi.68.2.787-796.1994
fatcat:ojpbbscb5jfipfczmdruv3t7zi