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The hydrolysis of hydantoin by various tissues
1946
Journal of Biological Chemistry
In 1912 Lewis (1) administered hydantoin to rabbits, cats, and dogs and came to the conclusion that the ring was not readily broken in the body. Gaebler and Keltch (2) some years later showed that some hydantoin was excreted as hydantoic acid after injection into dogs. Wada (3) claimed that urea was produced from hydantoin after incubation with milk or certain tissue suspensions. Finally, Kozelka and Hine (4) gave diphenylhydantoin to men and dogs and found that 1 to 5 per cent was excreted as
pmid:20985639
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