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Preparation and Evaluation of Chitosan Succinate Pellets Using Extrusion-Spheronization Technology: Processing and In Vitro Characterization
Turkish Journal of Pharmaceutical Sciences
The study is aimed to investigate a novel approach for the preparation of multiparticulate drug delivery system using chitosan succinate a chitosan derivatives polymer. Herein the chitosan succinate multiparticulate pellets ent-rapped diclofenac sodium was prepared by extrusion and spheronization technique. FTIR results revealed that there were no interactions between the drug and polymer. The prepared pellets were with good spherical geo-metry and 1.02±0.40 mm as their mean diameter. Chitosandoaj:7a14a6f2eb32489b87e61a1fc03b155b fatcat:jqqdl7me5zdhtjtukmjhgjs4a4