Major Histocompatibility Complex Haplotype Is Associated with Postherpetic Pain in Mice

Masako Sato-Takeda, Ichiro Takasaki, Kenji Takeda, Atsushi Sasaki, Tsugunobu Andoh, Hiroshi Nojima, Kimiyasu Shiraki, Yasushi Kuraishi, Kazuo Hanaoka, Katsushi Tokunaga, Toshio Yabe
2006 Anesthesiology  
Postherpetic neuralgia is one of the major complications of herpes zoster caused by the reactivation of varicella-zoster virus and is characterized by severe pain. The authors previously showed the association of a human major histocompatibility complex (MHC) haplotype with postherpetic neuralgia. This study was performed to experimentally confirm the role of MHC haplotype in the development of postherpetic pain using a mouse model of postherpetic pain, which corresponds to postherpetic
more » ... ostherpetic neuralgia. Methods: BALB/c mice (MHC haplotype: H-2 d ), C57BL/6 mice (MHC haplotype: H-2 b ), and BALB/b mice, a congenic BALB/c strain with H-2 b , were used. Herpes simplex virus type I was transdermally inoculated on the hind paw. Unilaterally zosteriform skin lesion and pain-related responses (acute herpetic pain) were caused, and some mice showed pain-related responses (postherpetic pain) after the cure of skin lesions. Herpes simplex virus type I antigen and CD3-positive cells were immunostained in the dorsal root ganglion in the acute phase. Results: The incidence (78%) of postherpetic pain in C57BL/6 mice was significantly higher than that (35%) in BALB/c mice (P ‫؍‬ 0.004, odds ratio ‫؍‬ 6.7). Furthermore, the incidence of postherpetic pain in BALB/b (H-2 b ) was similar to that in C57BL/6. Herpes simplex virus type I antigen-positive cells were less in the dorsal root ganglion of C57BL/6 mice than that of BALB/c mice. CD3-positive T cells were more in the dorsal root ganglion of C57BL/6 mice than BALB/c mice. Conclusions: These results suggest that the MHC haplotype (H-2 b ) is involved in the incidence of postherpetic pain, and CD3-positive T cells may play a role in its pathogenesis.
doi:10.1097/00000542-200605000-00024 pmid:16645460 fatcat:jw4r2sauebcvbpawsxc5hkayqi