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Complex systems theory is concerned with identifying and characterizing common design elements that are observed across diverse natural, technological and social complex systems. Systems biology, a more holistic approach to study molecules and cells in biology, has advanced rapidly in the past two decades. However, not much appreciation has been granted to the realization that the human cell is an exemplary complex system. Here, I outline general design principles identified in many complexdoi:10.1098/rsif.2017.0391 pmid:28931638 pmcid:PMC5636275 fatcat:qyjv2hvzbzccva4sbtlikmuzie