Complex systems biology

Avi Ma'ayan
2017 Journal of the Royal Society Interface  
Complex systems theory is concerned with identifying and characterizing common design elements that are observed across diverse natural, technological and social complex systems. Systems biology, a more holistic approach to study molecules and cells in biology, has advanced rapidly in the past two decades. However, not much appreciation has been granted to the realization that the human cell is an exemplary complex system. Here, I outline general design principles identified in many complex
more » ... ems, and then describe the human cell as a prototypical complex system. Considering concepts of complex systems theory in systems biology can illuminate our overall understanding of normal cell physiology and the alterations that lead to human disease. on November 3, 2017 http://rsif.royalsocietypublishing.org/ Downloaded from rsif.royalsocietypublishing.org J. R. Soc. Interface 14: 20170391
doi:10.1098/rsif.2017.0391 pmid:28931638 pmcid:PMC5636275 fatcat:qyjv2hvzbzccva4sbtlikmuzie