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Genetic Susceptibility to Multiple Sclerosis: Interactions between Conserved Extended Haplotypes of the MHC and other Susceptibility Regions
[post]
2020
unpublished
BACKGROUNDTo study the accumulation of MS-risk resulting from different combinations of MS-associated conserved-extended-haplotypes (CEHs) of the MHC and three non-MHC "risk-haplotypes" nearby genes EOMES, ZFP36L1, and CLEC16A. Many haplotypes are MS-associated despite having population-frequencies exceeding the percentage of genetically-susceptible individuals. The basis of this frequency-disparity requires explanation. MEHTODSWTCCC SNP-data was phased at the MHC and three non-MHC
doi:10.21203/rs.3.rs-77060/v1
fatcat:kc3mxgiewnfthpne6g3lyudqam